Thames Valley Police is at the scene of a fatal collision on the M1 in Buckinghamshire.
The incident happened between junctions 14 and 13 southbound shortly after 5am today.
A white Ford Transit van was involved in a collision with a white Iveco lorry. Two occupants of the van died at the scene. No further information is available about them at this time.
Police are investigating the cause of the incident and the main carriageway is closed southbound at this time. Traffic is backed up for 12 miles between junctions 15 and 13.
The hard shoulder is being used to try to ease congestion but there are lengthy tailbacks and motorists are advised to avoid the area.