Repair work will close the westbound A421 near Bedford overnight between Marston Moretaine and junction 13 of the M1 from Monday (November 23).
The work, which will consist of embankment and barrier repairs near Brogborough, will take place weeknights only between 9pm and 5.30am over four weeks, weather permitting.
Highways England project manager Kamal Ubhi said: “This work is necessary to ensure the continued safety of road users on this stretch of the A421.
“We have timed the work to be carried out when traffic levels are at their lowest and overnight but we are advising people to allow extra time for their journeys when the closures are in place.”
During the work, the westbound A421 will be closed and a clearly signed diversion will be in place to divert traffic along the old A421 (C94).
For the up to date traffic information, visit www.highways.gov.uk/traffic or follow @HighwaysEAST in the East of England.