Two men from Milton Keynes died after their car was in collision with a lorry in the early hours of Sunday.
The accident happened on the A5, near Kilsby in Northamptonshire close to the turning for Ashby St Ledgers, at about 12.10am.
A spokesman for Northamptonshire Police said: “A grey Audi A4, driven by a 31-year-old man from Milton Keynes, was travelling on the northbound carriageway when, for reasons yet unknown, it was in collision with a lorry travelling in the opposite direction.
“Sadly, both the driver and his passenger, a 37-year-old man also from Milton Keynes, died at the scene.
“The lorry driver, who was from Weston Super Mare, was unhurt,” the spokesperson added.
Witnesses or anyone with information is asked to call the Northamptonshire Police Drivewatch hotline on 0800 174615.