Protective measures will be place - including a free 50ml bottle of hand sanitiser given to each vehicle, along with a new guidebook printed with a special anti-viral coating.
Tickets must be bought online and in advance via the safari park's website here.
The park has updated its Penguin enclosure, complete with a bubble machine, during lockdown and also refurbished Monkey Mayhem area - home to Guianan Squirrel Monkeys.
A spokesman said: "In the Foot Safari, visitors will love the changes they’ll see to the Humboldt penguins enclosure, with a brand new expanded pool and updated viewing areas. Humboldt Harbour has been designed to mimic their natural habitat.
"The newly installed viewing windows will give visitors a unique insight into the complex system of burrows that the penguins make each year. While on the other side of the enclosure, you’ll be able to watch the penguins diving and playing below the surface of the water. The new bubble machine will also give visitors the chance to see just how playful these birds are."
He added: "And the mischievous troop of Guianan squirrel monkeys are ready to welcome you to their new home, Monkey Mayhem. Head over to watch as the monkeys show off their climbing skills as they move along the ropes, trees and vantage points in their new home, just as they would in the wild.
"With a new undercover viewing area, you can enjoy watching the troop as they play, forage, and move around their enclosure – keep an eye out for the adorable three youngsters, born in October last year."
There are also a few new residents to spot in the Road Safari - including the pair of one-year-old North American black bear cubs that have recently moved into the large drive-through enclosure.
Further around in the Road Safari, a herd of Blesbok antelope are settling into their new home that they share with the Rothschild’s giraffe herd.
The popular Bedfordshire Safari Park offers visitors of all ages an exciting and adventurous day out, seeing wild animals in wide open spaces.
"Visitors can explore and learn about amazing wildlife. Plus with much of the enjoyment spent on a safari drive or in the fresh air, there is the added bonus of having minimal contact with people from outside your household," said the spokesman.
Activities such as the Swan Boats, Great Woburn Railway, and outdoor play areas will all be open and included in the ticket price.