Roads and pedestrian crossing points will be closed from March 21.
The area around the Brunel roundabout will be under going essential works.
Road closures will be in place during this time in order to facilitate the works which will take place during the day.
The work is expected to take eight days to complete.
Diversions and clear signage will be in place to direct traffic and bus operators have been informed of these works.
For further information on the road closures visit www.roadworks.org
Temporary bus station departure points and diversion routes can be found on the Highways Hub at: www.milton-keynes.gov.uk/highways-and-transport-hub