Up to 1,300 adult learners will be refused a place at Milton Keynes College after £1million was slashed from its budget.
Further spending cuts announced by the government last week will mean college funding has reduced by 27 per cent in recent years.
College bosses say this will inevitably put the quality of teaching “under threat”.
Nick Isles (pictured), deputy principal, said: “For Milton Keynes College it means we will have to be very careful with how we manage our budgets in order to mitigate the effects of a cut of this magnitude.
“The quality, as well as the scale of the training we can give, will also come under threat.
“This will certainly make it difficult to continue to deliver the excellent service and experiences we have become accustomed to delivering.”
The cuts will affect 250 people doing full-time courses or up to 1,300 part-time students.
Apprenticeships will escape the cull with training set to continue in the next academic year, but plans are already being put in place to cope with financial pressures.
In a hard-hitting letter defending MK College, Iain Stewart MP asked for Minister Nick Boles MP to rethink his decision to cut 5 per cent of their total campus budget.
He said: “Milton Keynes is seeing strong local growth in areas such as engineering and construction.
“These are vital industries for our economy locally and nationally.
“I know the college has been working hard to meet the demand for the growth in these industries.
“However, staff attraction for these subjects is difficult and I would be bitterly disappointed if the college could not maintain and grow in these areas.
“I would ask the Department to take on board the concerns shared by MK College and re-look at the decision.”