The incident happened around 4am, in Fen Street, after three lorries were involved in a collision.
Two men were injured, but released before the fire service arrived.
The lorry was 100 per cent damaged by fire.
Fire crews from Broughton and one from West Ashland attended along with Police and South Central Ambulance Service.
The firefighters used two sets of breathing apparatus, one hose reel and thermal imaging camera.