Andrew Fisher and Tennai Watson
Their last defeat came on October 16 when they were beaten 2-1 by then League One pace setters Plymouth Argyle.
Their 2-1 win over Doncaster Rovers on Tuesday night saw them reclaim a play-off spot prior to Dons’ Wednesday night clash with Plymouth Argyle (full reaction online).
In eight meetings between the sides, Oxford have claimed three wins to Dons’ two.
Dons have also never beaten Oxford at Stadium MK, conceding deep into stoppage time when the sides met last season when Elliot Lee cancelled out Andrew Surman’s first half strike as the sides shared a 1-1 draw.
Tom Reeves will referee the match. In 18 games this season, he has flashed 66 yellows and two red cards. It will be his first time in charge of either side. Dean Treleaven and Lisa Rashid ill run the lines with Fourth Official Andy Bennett.
Bookies have Dons at 7/5 to win the game, Oxford at 1/10 and 12/5 the draw.