With Jordan Moore-Taylor, Baily Cargill, Mitch Hancox and George Williams now joined by the Welsh defender on the sidelines, manager Paul Tisdale has been forced into using midfielder Jordan Houghton at centre back recently.
Russell Martin, one of the three fit defenders left, said as much as consistency is preferred in the back line, injuries are a problem all teams have to overcome.
"You want continuity, of course," he said. "Jordan has done well when he's stepped in, he did well on Saturday and changed things for us, but it's one of those things.
Winkelman to discuss supporters’ issues ahead of Carabao Cup match
How MK Dons could line-up in the Carabao Cup against Sutton United
Pair sent for scans after limping out against Sheffield Wednesday
Chairman discusses parking, discounts and bottle tops at MK Dons
No rush to get in another striker after Grigg’s injury
"It has disrupted the flow, especially losing Joe Walsh who was a mainstay of the team while we were doing well. You want people fit and well, and hopefully they're starting to return and we hope it will give the manager fresh options. But you have to deal with these things whilst we have got injuries,and I think we've dealt with it well.
"Hopefully we will have a couple of people fit on Saturday, but if not, people need to be ready and step in."