Shaun Whalley scored the only goal of the game in an encounter with precious few chances. While Mo Eisa had a couple of sights in the first-half which he should have done better with, neither side were really able to carve out much in front of goal, with Whalley's 31st minute strike ultimately being the difference.
The result sees Dons drop to 18th in League Two, now nine without a win in the division.
Here’s how we rated the players at the Wham Stadium.
1. How we rated the MK Dons players in the defeat to Accrington
There wasn't much in the match between Dons and Accrington as Mike Williamson tried to implement his style of football in his first game in charge of the side from MK1 Photo: Lewis Storey
2. Craig MacGillivray
Some decent saves in either half to keep Accrington at bay. Played out with his feet a lot more than in the early season so far Photo: Jane Russell
3. Warren O'Hora - 5.5
Struggled with distribution for most of the game, with poor and misplaced passing summing up his afternoon Photo: Jane Russell
4. Daniel Harvie - 6
Solid return to the side at centre back after serving a ban. Not much chance to add to Dons' precious few attacks though, but he did create a good first-half chance for Dean Photo: Jane Russell