With questions about the formation, the midfield options and who will lead the line, the head coach could go with a similar looking side to the one which started against Barnet last Saturday in their final pre-season friendly.
Here, we have a go at guessing how Dons will line-up at the Abbey Stadium.
13. Option: Daniel Oyegoke
Brentford full-back Oyegoke is yet to make his senior bow and could get the opportunity against Cambridge, but is likely to be on the bench until he gets his feet further under the table at Stadium MK Photo: Harriet Lander
14. Option: Ethan Robson
A popular figure to return after his loan last term, and very capable of slotting straight back into the midfield Photo: Jane Russell
15. Option: Darragh Burns
Has been a livewire throughout pre-season and could add something on the right flank Photo: MK Dons
16. Option: Conor Grant
A regular for Rochdale last season, Grant can provide in the attacking third Photo: MK Dons