With questions about the formation, the midfield options and who will lead the line, the head coach could go with a similar looking side to the one which started against Barnet last Saturday in their final pre-season friendly.
Here, we have a go at guessing how Dons will line-up at the Abbey Stadium.
5. LB: Dean Lewington
After a couple of seasons at centre-back, don't be surprised if Lewington gets the nod at left-back on Saturday ahead of inexperienced Brentford loanee Daniel Oyegoke. Photo: Jane Russell
6. CM: Matt Smith
Didn't get to see a lot of Smith last season, but his performances in pre-season, and for Wales this summer have impressed Photo: MK Dons
7. CM: Josh McEachran
Grew in stature in the second half of last season, and is a logical choice to play in the centre of the park Photo: Jane Russell
8. AM: Dawson Devoy
A hotly tipped talent to play higher, Devoy arrives on English shores ready to prove himself. A regular in Ireland for Bohemians, so is already up to match fitness Photo: mk dons